Project P13

The role of ChREBP-dependent de novo lipogenesis in metabolic and thermogenic activities of brown and white adipose tissue

P13_1.JPG
© Scheja

Brown and beige adipocytes exhibit high de novo lipogenesis (DNL), the synthesis of endogenous fatty acids. The reasons for high DNL capacity in thermogenic adipose tissues are unknown. We have found that carbohydrate response element-binding protein (ChREBP) controls DNL enzymes in brown adipocytes. In this project, we want to explore how ChREBP isoforms regulate DNL and other cellular functions in thermogenic adipose tissue. Furthermore, we aim to identify mechanisms linking DNL to adaptive thermogenesis.


Project Leader

Avatar Scheja

Dr. rer. nat. Ludger Scheja

Gebäude N30, Raum 219

Martinistraße 52

20246 Hamburg

Universitätsklinikum Hamburg-Eppendorf

Institut für Biochemie und Molekulare Zellbiologie

+49 40 7410 57139

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