TRR333 BATenergy News Center

August 2022

New TRR333 BATenergy Publication

16.08.2022

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN. AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro. Mol Biol Cell. 2022 Aug 10;mbcE21110592. doi: 10.1091/mbc.E21-11-0592. Online ahead of print.

New TRR333 BATenergy Publication

16.08.2022

Khani S, Topel H, Josephrajan A, Larsen BD, de Almeida Tavanez AR, Gaudry MJ, Leyendecker P, Stanic N, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Engelhard CA, Nielsen S, Jespersen NZ, Rehimi R, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function. bioRxiv 2022.08.01.502156; doi: https://doi.org/10.1101/2022.08.01.502156


Juli 2022

New TRR333 BATenergy Publication

07.07.2022

Brown adipose tissue (BAT) dissipates energy and promotes cardio-metabolic health. In this publication, Nieman et al identifiy inosine as novel tissue-messenger in brown fat (BAT). They show that treatment of mice with inosine increased BAT-dependent energy expenditure and induced “browning” of white adipose tissue. This work was performed in close collaboration of projects P5, P10, P11, P15 and P16 of the CRC/TRR333 BATenergy.

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© Michelle Y. Jaeckstein and Jörg Heeren, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

Niemann, B., Haufs-Brusberg, S., Puetz, L. et al. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022). https://doi.org/10.1038/s41586-022-05041-0

New TRR333 BATenergy Publication

28.06.2022

Wiebke Fenske (Project P01) gladly announces the publication of one eminent manuscript with direct relevance for our TRR's mission in the highly respected journal MICROBIOME (IF(2021): 14.65)!

Importantly, this study represents a joint collaboration involving several members of TRR333: Wiebke Fenske, Thorsten Gnad, Alexander Pfeifer, Joerg Heeren

Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK. Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. PMID: 35739571; PMCID: PMC9229785.


April 2022

New TRR333 BATenergy Publication

22.04.2022

Oeckl J, Janovska P, Adamcova K, Bardova K, Brunner S, Dieckmann S, Ecker J, Fromme T, Funda J, Gantert T, Giansanti P, Hidrobo MS, Kuda O, Kuster B, Li Y, Pohl R, Schmitt S, Schweizer S, Zischka H, Zouhar P, Kopecky J, Klingenspor M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Mol Metab.
2022 Apr 22:101499. doi: 10.1016/j.molmet.2022.101499. Online ahead of print. PMID: 35470094


March 2022

New TRR333 BATenergy Publication

29.03.2022

Thiemann E, Schwaerzer GK, Evangelakos I, Fuh MM, Jaeckstein MY, Behrens J, Nilsson SK, Kumari M, Scheja LPfeifer AHeeren J, Heine M. Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling. Front Physiol.
2022 Mar 29;13:859671. doi: 10.3389/fphys.2022.859671. eCollection 2022. PMID: 35422714

New TRR333 BATenergy Publication

29.03.2022

Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor MPfeifer A, Gnad T. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol.
2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968

ERC Consolidator Grant for our TRR333 Project Leader Prof. Felix Meißner!

17.03.2022

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© Prof. Felix Meissner

Prof. Dr. Felix Meißner has now received an ERC Consolidator Grant for his research. The project “FIREALARM” is funded with around 2 million euros.  


February 2022

New TRR333 BATenergy Publication

22.02.2022

Li YFromme T. Uncoupling Protein 1 Does Not Produce Heat without Activation. Int J Mol Sci.
2022 Feb 22;23(5):2406. doi: 10.3390/ijms23052406. PMID: 35269549 

New TRR333 BATenergy Publication

11.02.2022

Rohde JK, Fuh MM, Evangelakos I, Pauly MJ, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren JWorthmann A. A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids. Metabolites.
2022 Feb 11;12(2):170. doi: 10.3390/metabo12020170. PMID: 35208244

New TRR333 BATenergy Publication

01.02.2022

Dieckmann S, Strohmeyer A, Willershäuser M, Maurer SF, Wurst W, Marschall S, de Angelis MH, Kühn R, Worthmann A, Fuh MM, Heeren J, Köhler N, Pauling JK, Klingenspor M. Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1. Am J Physiol Endocrinol Metab.
2022 Feb 1;322(2):E85-E100. doi: 10.1152/ajpendo.00278.2021. Epub 2021 Dec 20.PMID: 34927460


January 2022

New TRR333 BATenergy Publication

Heine M, Corban C, Heeren J. Methods Mol Biol. Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice. 2022;2448:107-118. doi: 10.1007/978-1-0716-2087-8_7. PMID: 35167093


December 2021

Professor Emeritus Jean Himms‐Hagen passed away

01.12.2022

Professor Emeritus Jean Himms‐Hagen passed away on December 1, 2021. Jean will be fondly 4 remembered by many for her foundational contributions to research on brown adipose tissue 5 metabolism and physiology, and for her extensive contributions to education, service, and 6 leadership. She was a long‐standing member of the American Society of Physiology, published 7 extensively in the American Journal of Physiology: Endocrinology and Metabolism, and served 8 as a reviewer throughout her career and well into her retirement....


Contact

Lena Graziola

Universitätsklinikum Bonn

Institut für Pharmakologie & Toxikologie

Venusberg-Campus 1 53127 Bonn

+49 228 287-51300

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