Publications of the TRR 333

Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK. Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. PMID: 37289866.

Raimúndez E, Fedders M, Hasenauer J. Posterior marginalization accelerates Bayesian inference for dynamical systems. bioRxiv 2022.12.02.518841; doi: https://doi.org/10.1101/2022.12.02.518841

Till, A, Fries, C, Fenske, W.K. Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose  Tissue in Development and Therapy of Obesity. Brain Sci. 2022, 12, 1646. https://doi.org/10.3390/brainsci12121646

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN. AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro. Mol Biol Cell. 2022 Aug 10;mbcE21110592. doi: 10.1091/mbc.E21-11-0592. Online ahead of print.

Khani S, Topel H, Josephrajan A, Larsen BD, de Almeida Tavanez AR, Gaudry MJ, Leyendecker P, Stanic N, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Engelhard CA, Nielsen S, Jespersen NZ, Rehimi R, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function. bioRxiv 2022.08.01.502156; doi: https://doi.org/10.1101/2022.08.01.502156

Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Müller CE, Tönjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature. 2022 Sep;609(7926):361-368. doi: 10.1038/s41586-022-05041-0. Epub 2022 Jul 5. PMID: 35790189; PMCID: PMC9452294.

Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK. Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. PMID: 35739571; PMCID: PMC9229785.

Oeckl J, Janovska P, Adamcova K, Bardova K, Brunner S, Dieckmann S, Ecker J, Fromme T, Funda J, Gantert T, Giansanti P, Hidrobo MS, Kuda O, Kuster B, Li Y, Pohl R, Schmitt S, Schweizer S, Zischka H, Zouhar P, Kopecky J, Klingenspor M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Mol Metab.
2022 Apr 22:101499. doi: 10.1016/j.molmet.2022.101499. Online ahead of print. PMID: 35470094

Thiemann E, Schwaerzer GK, Evangelakos I, Fuh MM, Jaeckstein MY, Behrens J, Nilsson SK, Kumari M, Scheja L, Pfeifer A, Heeren J, Heine M. Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling. Front Physiol.
2022 Mar 29;13:859671. doi: 10.3389/fphys.2022.859671. eCollection 2022. PMID: 35422714

Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol.
2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968

Rohde JK, Fuh MM, Evangelakos I, Pauly MJ, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A. A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids. Metabolites.
2022 Feb 11;12(2):170. doi: 10.3390/metabo12020170. PMID: 35208244

Li Y, Fromme T. Uncoupling Protein 1 Does Not Produce Heat without Activation. Int J Mol Sci.
2022 Feb 22;23(5):2406. doi: 10.3390/ijms23052406. PMID: 35269549 

Heine M, Corban C, Heeren J. Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice. Methods Mol Biol.
2022;2448:107-118. doi:  10.1007/978-1-0716-2087-8_7. PMID: 35167093