Highlights and Publications
2025
Köker SC, Tsokanos FF, El-Merahbi R, Jha AK, Cicatelli K, Weber P, Mhamane A, Kaltenecker D, Morigny P, Loft A, Klepac K, Maida A, Molocea CE, Hass D, Vogl ES, Alfaro AJ, Sun W, Zitzelsberger H, Unger K, Szendrödi J, Li Y, Diaz MB, Wolfrum C, Bartelt A, Herzig S, Georgiadi A. The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure. FASEB J. 2025 Aug 15;39(15):e70886. doi: 10.1096/fj.202402993RRR. PMID: 40787784; PMCID: PMC12337241.
Braunsperger A, Bauer M, Brahim CB, Seep L, Tischer D, Peitzsch M, Hasenauer J, Figueroa SH, Worthmann A, Heeren J, Dyar KA, Koehler K, Soriano-Arroquia A, Schönfelder M, Wackerhage H. Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath. Sci Rep. 2025 Jan 8;15(1):1263. doi: 10.1038/s41598-025-85304-8. PMID: 39779795; PMCID: PMC11711488.
Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park JH, Schauss A, Peltzer N, Brüning JC, Kornfeld JW, Pfeifer A, Langer T, Lusic M, Wickström SA, Frezza C, Trifunovic A. 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nat Metab. 2025 Aug;7(8):1593-1613. doi: 10.1038/s42255-025-01332-8. Epub 2025 Aug 1. PMID: 40750944; PMCID: PMC12373511.
Hildebrand S, Pfeifer A. The obesity pandemic and its impact on non-communicable disease burden. Pflugers Arch. 2025 May;477(5):657-668. doi: 10.1007/s00424-025-03066-8. Epub 2025 Feb 10. PMID: 39924587; PMCID: PMC12003543.
Seep L, Jost PJ, Lisowski C, Huang H, Grein S, Hermannsdottir H, Kuellmer K, Fromme T, Klingenspor M, Mass E, Kurts C, Hasenauer J. cOmicsArt-a customizable Omics Analysis and reporting tool. Bioinform Adv. 2025 Apr 1;5(1):vbaf067. doi: 10.1093/bioadv/vbaf067. PMID: 40385593; PMCID: PMC12085238.
Huang H, Balzer NR, Seep L, Splichalova I, Blank-Stein N, Viola MF, Franco Taveras E, Acil K, Fink D, Petrovic F, Makdissi N, Bayar S, Mauel K, Radwaniak C, Zurkovic J, Kayvanjoo AH, Wunderling K, Jessen M, Yaghmour MH, Kenner L, Ulas T, Grein S, Schultze JL, Scott CL, Guilliams M, Liu Z, Ginhoux F, Beyer MD, Thiele C, Meissner F, Hasenauer J, Wachten D, Mass E. Kupffer cell programming by maternal obesity triggers fatty liver disease. Nature. 2025 Aug;644(8077):790-798. doi: 10.1038/s41586-025-09190-w. Epub 2025 Jun 18. PMID: 40533564; PMCID: PMC12367551.
Sieckmann K, Winnerling N, Silva Ribeiro DJ, Yüksel S, Kardinal R, Steinheuer LM, Frechen F, Corrêa LH, Schermann G, Klausen C, Blank-Stein N, Schulte-Schrepping J, Osei-Sarpong C, Becker M, Bonaguro L, Beyer M, May-Simera HL, Zurkovic J, Thiele C, Thurley K, Sorokin L, Ruiz de Almodovar C, Mass E, Wachten D. BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue. EMBO J. 2025 Oct;44(19):5315-5336. doi: 10.1038/s44318-025-00524-y. Epub 2025 Aug 20. PMID: 40836034; PMCID: PMC12489102.
Hidrobo MS, Höring M, Brunner S, Liebisch G, Schweizer S, Klingenspor M, Schreiber R, Zechner R, Burkhardt R, Ecker J. Cold-induced phosphatidylethanolamine synthesis in liver and brown adipose tissue of mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jan;1870(1):159562. doi: 10.1016/j.bbalip.2024.159562. Epub 2024 Aug 28. PMID: 39214167.
Loipfinger S, Grosholz M, Kumar S, Erbilir H, Dyar KA, Müller TD, Grein S, Rozman J, Klingenspor M, Meyer C, Lutter D. Calopy - an advanced framework for the integration and analysis of indirect calorimetry data. Nat Metab. 2025 Jun;7(6):1093-1095. doi: 10.1038/s42255-025-01316-8. PMID: 40562969.
Zhong J, Zareifi D, Weinbrenner S, Hansen M, Klingelhuber F, Nono Nankam PA, Frendo-Cumbo S, Bhalla N, Cordeddu L, de Castro Barbosa T, Arner P, Dahlman I, Muniandy M, Heinonen S, Pietiläinen KH, Hoffmann A, Ghosh A, John D, Tönjes A, Ståhl PL, Böttcher Y, Keller M, Kovacs P, Kerr AG, Langin D, Wolfrum C, Blüher M, Krahmer N, Massier L, Mejhert N, Rydén M. adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue. Cell Metab. 2025 Mar 4;37(3):566-569. doi: 10.1016/j.cmet.2025.01.012. Epub 2025 Feb 20. PMID: 39983713.
Nicolaisen TS, Lyster AE, Sjøberg KA, Haas DT, Voldstedlund CT, Lundsgaard AM, Jensen JK, Madsen EM, Nielsen CK, Bloch-Ibenfeldt M, Wewer Albrechtsen NJ, Rose AJ, Krahmer N, Clemmensen C, Richter EA, Fritzen AM, Kiens B. Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. Nat Metab. 2025 Mar;7(3):602-616. doi: 10.1038/s42255-025-01236-7. Epub 2025 Mar 6. PMID: 40050437; PMCID: PMC11946896.
Couchet M, Gao H, Klingelhuber F, Jalkanen J, De Castro Barbosa T, Omar-Hmeadi M, Massier L, Krahmer N, Mejhert N, Rydén M. Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue. Adipocyte. 2025 Dec;14(1):2283213. doi: 10.1080/21623945.2023.2283213. Epub 2025 Jun 5. PMID: 37982546; PMCID: PMC12147497.
A Wagner, JH Lautaoja-Kivipelto, K Pehkonen, A Hassinen, M Kuusela, L Röttger, E Herbers, A Ioannidou, S Mädler, I Rothenaigner, S Srinivasan, S Laasonen, MT Rahman, P Elomaa, S Kortetjärvi, A Olsson, O Ukkola, K Hadian, M Mann, H Peltoniemi, KH Pietiläinen, M Klingenspor, KA Virtanen, CE Hagberg, E Pirinen. In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds. bioRxiv 2025.04.16.649074; doi: https://doi.org/10.1101/2025.04.16.649074
Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nat Metab. 2024 Apr 29. doi: 10.1038/s42255-024-01033-8. Epub ahead of print. PMID: 38684889. Publication
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A. EPAC1 enhances brown fat growth and beige adipogenesis. Nat Cell Biol. 2024 Jan;26(1):113-123. doi: 10.1038/s41556-023-01311-9. Epub 2024 Jan 9. PMID: 38195707; PMCID: PMC10791580. Publication
Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz JJ, Kundu S, Fuh MM, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich CF, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use. Nat Commun. 2024 Jan 2;15(1):45. doi: 10.1038/s41467-023-44364-y. PMID: 38167725; PMCID: PMC10762034. Publication
Wackerhage H, Hinrichs A, Wolf E, Hrabě de Angelis M. Turning fat into muscle: can this be an alternative to anti-obesity drugs such as semaglutide? J Physiol. 2024 Mar 1. doi: 10.1113/JP286430. Epub ahead of print. PMID: 38426245. Publication
Graelmann F, Gondorf F, Majlesain Y, Niemann B, Klepac K, Gottschalk M, Mayer M, Iriady I, Hatzfeld P, Lindenberg S, Wunderling K, Thiele C, Abdullah Z, He W, Hiller K, Haendler K, Beyer M, Ulas T, Pfeifer A, Esser C, Weighardt H, Förster I, Reverte-Salisa L. Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis. bioRxiv 2024.02.22.581524; doi: https://doi.org/10.1101/2024.02.22.581524 Publication
Pfeifer A, Mikhael M, Niemann B. Inosine: novel activator of brown adipose tissue and energy homeostasis. Trends Cell Biol. 2024 Jan;34(1):72-82. doi: 10.1016/j.tcb.2023.04.007. Epub 2023 May 13. PMID: 37188562. Publication
Quagliarini F, Makris K, Friano ME, Uhlenhaut NH. EJE Prize 2023: genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor. Eur J Endocrinol. 2023 May 10;188(5):R111-R130. doi: 10.1093/ejendo/lvad048. PMID: 37119521. Publication
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M. Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 2023 Dec 20. doi: 10.1038/s41586-023-06857-0. Epub ahead of print. PMID: 38123683. Publication
De Jong KA, Ehret S, Heeren J, Nikolaev VO. Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes. Cell Rep. 2023 May 30;42(5):112433. doi: 10.1016/j.celrep.2023.112433. Epub 2023 Apr 25. PMID: 37099421. Publication
Correia CM, Præstholm SM, Havelund JF, Pedersen FB, Siersbæk MS, Ebbesen MF, Gerhart-Hines Z, Heeren J, Brewer J, Larsen S, Blagoev B, Færgeman NJ, Grøntved L. Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice. Endocrinology. 2023 Aug 28;164(10):bqad128. doi: 10.1210/endocr/bqad128. PMID: 37610219. Publication
Siracusa F, Schaltenberg N, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N. Short-term dietary changes can result in mucosal and systemic immune depression. Nat Immunol. 2023 Sep;24(9):1473-1486. doi: 10.1038/s41590-023-01587-x. Epub 2023 Aug 14. PMID: 37580603; PMCID: PMC10457203. Publication
Schälte, Y., Fröhlich, F., Jost, P. J., Vanhoefer, J., Pathirana, D., Stapor, P., Lakrisenko, P., Wang, D., Raimúndez, E., Merkt, S., Schmiester, L., Städter, P., Grein, S., Dudkin, E., Doresic, D., Weindl, D., & Hasenauer, J. (2023). pyPESTO: A modular and scalable tool for parameter estimation for dynamic models, Bioinformatics, 2023, btad711, doi:10.1093/bioinformatics/btad711 Publication
Villaverde AF, Raimundez E, Hasenauer J, Banga JR. Assessment of Prediction Uncertainty Quantification Methods in Systems Biology. IEEE/ACM Trans Comput Biol Bioinform. 2023 May-Jun;20(3):1725-1736. doi: 10.1109/TCBB.2022.3213914. Epub 2023 Jun 5. PMID: 36223355. Publication
Raimúndez E, Fedders M, Hasenauer J. Posterior marginalization accelerates Bayesian inference for dynamical models of biological processes. iScience. 2023 Sep 28;26(11):108083. doi: 10.1016/j.isci.2023.108083. PMID: 37867942; PMCID: PMC10589897. Publication
Swietlik JJ, Bärthel S, Falcomatà C, Fink D, Sinha A, Cheng J, Ebner S, Landgraf P, Dieterich DC, Daub H, Saur D, Meissner F. Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nat Commun. 2023 May 8;14(1):2642. doi: 10.1038/s41467-023-38171-8. PMID: 37156840; PMCID: PMC10167354. Publication
Schlein C, Worthmann A, Piel S et al. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use, 21 November 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1008467/v1] Publication
Sun L, Laurila S, Lahesmaa M, Rebelos E, Virtanen KA, Schnabl K, Klingenspor M, Nummenmaa L, Nuutila P. Secretin modulates appetite via brown adipose tissue-brain axis. Eur J Nucl Med Mol Imaging. 2023 May;50(6):1597-1606. doi: 10.1007/s00259-023-06124-4. Epub 2023 Feb 11. PMID: 36764966; PMCID: PMC10119257. Publication
Chamorro R, Jouffe C, Oster H, Uhlenhaut NH, Meyhöfer SM. When should I eat: A circadian view on food intake and metabolic regulation. Acta Physiol (Oxf). 2023 Mar;237(3):e13936. doi: 10.1111/apha.13936. Epub 2023 Jan 27. PMID: 36645134. Publication
Fadel L, Dacic M, Fonda V, Sokolsky BA, Quagliarini F, Rogatsky I, Uhlenhaut NH. Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators. Pharmacol Ther. 2023 Nov;251:108531. doi: 10.1016/j.pharmthera.2023.108531. Epub 2023 Sep 16. PMID: 37717739. Publication
Haumann F, Evangelakos I, Worthmann A, Liebold I, Kotschi S, Bischoff AT, Neuhofer CM, Schweizer M, Heine M, the mitoNET consortium, Büchner B, Klopstock T, Prehn C, Dyar KA, Prokisch H, Bosurgi L, Heeren J, Bartelt A, Kubisch C, Schlein C. Mitochondrial fatty acid synthesis is essential for coordinated energy transformation. medRxiv 2023.04.03.23288010; doi: https://doi.org/10.1101/2023.04.03.23288010 Publication
Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Hölzl S, Scheja L, Heeren J, Kratky D, Huber LA. The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue. Mol Metab. 2023 May;71:101705. doi: 10.1016/j.molmet.2023.101705. Epub 2023 Mar 11. PMID: 36907508; PMCID: PMC10074977. Publication
Deline ML, Straub J, Patel M, Subba P, Grashei M, van Heijster FHA, Pirkwieser P, Somoza V, Livingstone JD, Beazely M, Kendall B, Gingras MJP, Leonenko Z, Höschen C, Harrington G, Kuellmer K, Bian W, Schilling F, Fisher MPA, Helgeson ME, Fromme T. Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity. Front Physiol. 2023 Sep 15;14:1200119. doi: 10.3389/fphys.2023.1200119. PMID: 37781224; PMCID: PMC10540846. Publication
U-Din M, de Mello VD, Tuomainen M, Raiko J, Niemi T, Fromme T, Klåvus A, Gautier N, Haimilahti K, Lehtonen M, Kristiansen K, Newman JW, Pietiläinen KH, Pihlajamäki J, Amri EZ, Klingenspor M, Nuutila P, Pirinen E, Hanhineva K, Virtanen KA. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. Cell Rep. 2023 Sep 26;42(9):113131. doi: 10.1016/j.celrep.2023.113131. Epub 2023 Sep 13. PMID: 37708023. Publication
U-Din M, Rebelos E, Saari T, Niemi T, Kuellmer K, Eskola O, Fromme T, Rajander J, Taittonen M, Klingenspor M, Nuutila P, Nummenmaa L, Virtanen KA. Thermogenic Capacity of Human Supraclavicular Brown Fat and Cold-Stimulated Brain Glucose Metabolism. Metabolites. 2023 Mar 5;13(3):387. doi: 10.3390/metabo13030387. PMID: 36984827; PMCID: PMC10055954. Publication
Hiefner J, Rische J, Bunders MJ, Worthmann A. A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples. Front Immunol. 2023 Sep 20;14:1250762. doi: 10.3389/fimmu.2023.1250762. PMID: 37799723; PMCID: PMC10548204. Publication
Liebold I, Meyer S, Heine M, Kuhl A, Witt J, Eissing L, Fischer AW, Koop AC, Kluwe J, Wiesch JSZ, Wehmeyer M, Knippschild U, Scheja L, Heeren J, Bosurgi L, Worthmann A. TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD. Cells. 2023 Jan 17;12(3):341. doi: 10.3390/cells12030341. PMID: 36766683; PMCID: PMC9913311. Publication
Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK. Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. PMID: 37289866. Publication
Benzi A, Spinelli S, Sturla L, Heine M, Fischer AW, Koch-Nolte F, Mittrücker HW, Guse AH, De Flora A, Heeren J, Bruzzone S. Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice. Cells. 2022 Nov 28;11(23):3812. doi: 10.3390/cells11233812. PMID: 36497069; PMCID: PMC9738612. Publication
Fischer AW, Jaeckstein MY, Heeren J. Lysosomal acid lipase promotes endothelial proliferation in cold-activated adipose tissue. Adipocyte. 2022 Dec;11(1):28-33. doi: 10.1080/21623945.2021.2013416. PMID: 34957913; PMCID: PMC8726628. Publication
Müller AL, Casar C, Preti M, Krzikalla D, Gottwick C, Averhoff P, Rosenstiel P, Gelderblom M, Altfeld M, Lohse AW, Steinmann S, Sebode M, Krause J, Schwinge D, Schramm C, Carambia A, Herkel J. Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis. J Hepatol. 2022 Dec;77(6):1532-1544. doi: 10.1016/j.jhep.2022.06.025. Epub 2022 Jul 5. PMID: 35798133. Publication
Evangelakos I, Kuhl A, Baguhl M, Schlein C, John C, Rohde JK, Heine M, Heeren J, Worthmann A. Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice. Front Cell Dev Biol. 2022 Apr 11;10:836741. doi: 10.3389/fcell.2022.836741. PMID: 35478959; PMCID: PMC9038073. Publication
Bruder J, Fromme T. Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice. Front Endocrinol (Lausanne). 2022 Feb 17;13:849877. doi: 10.3389/fendo.2022.849877. PMID: 35250892; PMCID: PMC8892685. Publication
van Zwol, W; Rimbert, A; Wolters, J C.; Smit, M; Bloks, V W.; Kloosterhuis, N J.; Huijkman, N C. A.; Koster, M H.; Tharehalli, U; de Neck, S M.; Bournez, C; Fuh, M M.; Kuipers, J; Rajan, S; de Bruin, A; Ginsberg, H N.; van Westen, G J. P.; Hussain, M. M; Scheja, L; Heeren, J; Zimmerman, P; van de Sluis, B; Kuivenhoven, J A*. Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. Hepatology ():p n/a, October 12, 2022. | DOI: 10.1002/hep.32709 Publication
Raimúndez E, Fedders M, Hasenauer J. Posterior marginalization accelerates Bayesian inference for dynamical systems. bioRxiv 2022.12.02.518841; doi: https://doi.org/10.1101/2022.12.02.518841 Publication
Till, A, Fries, C, Fenske, W.K. Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose Tissue in Development and Therapy of Obesity. Brain Sci. 2022, 12, 1646. https://doi.org/10.3390/brainsci12121646 Publication
Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN. AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro. Mol Biol Cell. 2022 Aug 10;mbcE21110592. doi: 10.1091/mbc.E21-11-0592. Online ahead of print. Publication
Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Müller CE, Tönjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature. 2022 Sep;609(7926):361-368. doi: 10.1038/s41586-022-05041-0. Epub 2022 Jul 5. PMID: 35790189; PMCID: PMC9452294. Publication
Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK. Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. PMID: 35739571; PMCID: PMC9229785. Publication
Oeckl J, Janovska P, Adamcova K, Bardova K, Brunner S, Dieckmann S, Ecker J, Fromme T, Funda J, Gantert T, Giansanti P, Hidrobo MS, Kuda O, Kuster B, Li Y, Pohl R, Schmitt S, Schweizer S, Zischka H, Zouhar P, Kopecky J, Klingenspor M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Mol Metab.
2022 Apr 22:101499. doi: 10.1016/j.molmet.2022.101499. Online ahead of print. PMID: 35470094 Publication
Thiemann E, Schwaerzer GK, Evangelakos I, Fuh MM, Jaeckstein MY, Behrens J, Nilsson SK, Kumari M, Scheja L, Pfeifer A, Heeren J, Heine M. Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling. Front Physiol.
2022 Mar 29;13:859671. doi: 10.3389/fphys.2022.859671. eCollection 2022. PMID: 35422714 Publication
Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol.
2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968 Publication
Rohde JK, Fuh MM, Evangelakos I, Pauly MJ, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A. A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids. Metabolites.
2022 Feb 11;12(2):170. doi: 10.3390/metabo12020170. PMID: 35208244 Publication
Li Y, Fromme T. Uncoupling Protein 1 Does Not Produce Heat without Activation. Int J Mol Sci.
2022 Feb 22;23(5):2406. doi: 10.3390/ijms23052406. PMID: 35269549 Publication
Heine M, Corban C, Heeren J. Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice. Methods Mol Biol.
2022;2448:107-118. doi: 10.1007/978-1-0716-2087-8_7. PMID: 35167093 Publication
Dieckmann S, Strohmeyer A, Willershäuser M, Maurer SF, Wurst W, Marschall S, de Angelis MH, Kühn R, Worthmann A, Fuh MM, Heeren J, Köhler N, Pauling JK, Klingenspor M. Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1. Am J Physiol Endocrinol Metab.
2022 Feb 1;322(2):E85-E100. doi: 10.1152/ajpendo.00278.2021. Epub 2021 Dec 20.PMID: 34927460 Publication
