Welcome to the web page of the CRC/TRR333
The Collaborative Research Center (CRC) TRR333 Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy) is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) and investigates metabolism/diabetes and focuses on brown adipose tissue.
Recent publication in Nature!
Brown adipose tissue (BAT) dissipates energy and promotes cardio-metabolic health. In this publication, Nieman et al identifiy inosine as novel tissue-messenger in brown fat (BAT). They show that treatment of mice with inosine increased BAT-dependent energy expenditure and induced “browning” of white adipose tissue. This work was performed in close collaboration of projects P5, P10, P11, P15 and P16 of the CRC/TRR333 BATenergy.
Niemann, B., Haufs-Brusberg, S., Puetz, L. et al. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022). https://doi.org/10.1038/s41586-022-05041-0
Participating universities and research institutions
The University of Bonn, the Universität Hamburg, the Technical University of Munich and the Helmholtz Center Munich are leading research organizations in the field of brown and beige adipose tissue in Germany. The CRC/TRR333 constitutes a unique possibility to bring together leading scientists in the field of brown and beige adipose tissue and energy homeostasis and foster their interaction. All participating institutions offer state-of-the-art research infrastructure and an outstanding environment for excellent research.
Contact
TRR333 BATenergy Office Bonn
Lena Graziola
Universitätsklinikum Bonn
Institut für Pharmakologie & Toxikologie
Venusberg-Campus 1 53127 Bonn
