Project P12

The role of ACTH and glucocorticoid signaling in brown fat metabolism

GR binding at the Fabp4 locus.jpg
GR binding at the Fabp4 locus.jpg © Prof. Henriette Uhlenhaut

Endocrine signals from the Hypothalamic-Pituitary-Adrenal (HPA) axis control metabolic pathways in many tissues, including brown fat. Indeed, ACTH stimulates, while glucocorticoids inhibit thermogenesis. Here we aim to dissect the physiological effects of the HPA axis on brown fat function. We will decipher the crosstalk between glucocorticoid, ACTH, lipid and cytokine signaling under various conditions such as feeding, cold and high fat diet challenges using mouse genetics, genomics, metabolomics and proteomics. We will determine the relevance of these pathways and their intersection in brown fat function and metabolic disease.

Project Leaders

Avatar Uhlenhaut

Prof. Dr. rer. nat. Nina Henriette Uhlenhaut

Chair for Metabolic Programming TUM School of Life Sciences Weihenstephan & ZIEL-Institute for Food & Health

Gregor-Mendel-Str. 2

85354 Freising

Director Institute for Diabetes and Endocrinology (IDE) Helmholtz Zentrum München

Ingolstaedter Landstr. 1

85764 Neuherberg

Avatar Li

Prof. Dr. rer. nat. Yongguo Li

University Hospital, University of Bonn

Institute of Pharmacology and Toxicology

Venusberg-Campus 1 53127 Bonn

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