Project P14

Molecular role of the mitochondrial unfolded protein response in white and brown adipose tissue for whole body glucose homeostasis

P14 Graphical summary.png
© Dr. Eva Rath

Functional disturbances of adipocyte mitochondria can affect systemic glucose tolerance via adipocyte-intrinsic mechanisms like impaired glucose uptake and altered differentiation processes (e.g. browning of WAT) as well as via metabolic- or endocrine-derived signals to remote tissues. Using new conditional knockout mouse models and high-fat diet feeding in combination with interventional studies employing pharmacological relevant substances, this project aims to unravel the role of MT-UPR signaling for the maintenance of adipocyte functions in WAT and BAT and its contribution to sustain whole body glucose homeostasis.


Project Leaders

Avatar Klingenspor

Prof. Dr. rer. nat. Martin Klingenspor

Raum 1.89

Gregor-Mendel-Straße 2

85354 Freising

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich

EKFZ – Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich

ZIEL – Institute for Food & Health, Technical University of Munich

+49 8161 71-2386

Avatar Rath

Dr. rer. nat. Eva Rath

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Lehrstuhl für Ernährung und Immunologie

Gregor-Mendel-Straße 2

85354 Freising

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