Project P17

The role of fatty acid/triglyceride cycling in maintenance of mitochondrial integrity and cellular health, and its contribution to thermogenesis in adipose tissues

Thermogenic futile cycling in brown and beige adipocytes. This figure was created using https://smart.servier.com
Thermogenic futile cycling in brown and beige adipocytes. This figure was created using https://smart.servier.com © Prof. Martin Klingenspor

Brown adipocytes lacking uncoupling protein 1 recruit a futile fatty acid/triglyceride (FA/TG) cycle for thermogenesis. Futile FA/TG cycling may control intracellular free FA levels, and thereby avert lipotoxicity. We aim to elucidate the role of previously identified key enzymes, and study the mutual relation between the lipid droplet-mitochondria interaction and FA/TG cycling. We will investigate the impact of FA/TG cycling on the cellular lipidome, organelle as well as cellular crosstalk, and energy expenditure.


Project Leader

Avatar Klingenspor

Prof. Dr. rer. nat. Martin Klingenspor

Raum 1.89

Gregor-Mendel-Straße 2

85354 Freising

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich

EKFZ – Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich

ZIEL – Institute for Food & Health, Technical University of Munich

+49 8161 71-2386

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