Project P03

Investigating novel endocrine signals of liver - white and brown adipose tissue cross talk in response to cold exposure and feeding cues

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Georgiadi/Herzig

We recently identified the ligand-receptor FNDC4-GPR116 signaling pathway and demonstrated that it mediates a liver - WAT cross talk, controlling systemic glucose homeostasis. In this project, we will investigate the role of this novel hormone and its receptor in cold and feeding patterns/diet-induced adaptive thermogenesis. In addition, we will clarify the adipose tissue depots and species-specific differences of this novel signaling pathway.


Project Leaders

Avatar Georgiadi

Anastasia Georgiadi

Ph.D.

Ingolstädter Langstraße 1

85764 Neuherberg

Junior Group Leader: Endocrine Pharmcology (ENP)

Institute of Diabetes and Cancer (IDC)

+49 89 3187-1808

Avatar Herzig

Prof. Stephan Herzig

Ph.D.

Professor and Research Director Helmholtz Munich

Ingolstädter Landstraße 1

85764 Neuherberg

Head of Department

Helmholtz Diabetes Center HDC

Joint Heidelberg-IDC Translational Diabetes Unit Heidelberg University Hospital

+49 89 3187-1045

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