Project P03
Investigating novel endocrine signals of liver - white and brown adipose tissue cross talk in response to cold exposure and feeding cues
© Georgiadi/Herzig
We recently identified the ligand-receptor FNDC4-GPR116 signaling pathway and demonstrated that it mediates a liver - WAT cross talk, controlling systemic glucose homeostasis. In this project, we will investigate the role of this novel hormone and its receptor in cold and feeding patterns/diet-induced adaptive thermogenesis. In addition, we will clarify the adipose tissue depots and species-specific differences of this novel signaling pathway.
Project Leaders
Anastasia Georgiadi
Ph.D.
Ingolstädter Langstraße 1
85764 Neuherberg
Junior Group Leader: Endocrine Pharmcology (ENP)
Institute of Diabetes and Cancer (IDC)
© Michael Haggenmüller
Prof. Stephan Herzig
Ph.D.
Professor and Research Director Helmholtz Munich
Ingolstädter Landstraße 1
85764 Neuherberg
Head of Department
Helmholtz Diabetes Center HDC
Joint Heidelberg-IDC Translational Diabetes Unit Heidelberg University Hospital
© Jan Roeder