Project P04

ExBat: Effect of acute and chronic exercise on human thermogenic adipose tissue & elucidation of mechanisms

© Wackerhage/Soriano

Exercise has many beneficial effects including a regulation of adaptive thermogenesis. Centered around the finding that exercise-conditioned sera from athletes enhance human adipocyte UCP1 expression, we will investigate the effect of different exercise modes and of exercise training on adaptive thermogenesis in humans. Mechanistically, this project will specifically investigate metabolites that regulate “browning” via phosphoproteomics and whether miRNAs in exosomes, termed exomiRs, mediate crosstalk in-between muscle and adipocytes especially during exercise.

Project Leaders

Avatar Wackerhage

Prof. Dr. Henning Wackerhage

Fakultät für Sport- und Gesundheitswissenschaften

Conollystraße 32

80809 München

Avatar Soriano Arroquia

Dr. Ana Soriano Arroquia

Institut für Pharmakologie und Toxikologie, Biomedizinisches Zentrum

Venusberg-Campus 1

53127 Bonn

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