Project P06
Interactions of endothelium and adipocytes during thermogenic adaptation
© AP
Brown adipose tissue (BAT) is highly vascularized. Changes in BAT functional states also stimulate the adaptation of the BAT vascular network. This suggests that there is a crosstalk between adipocytes and endothelial cells (ECs). So far, this is only poorly understood and the existing studies focus on angiogenesis in BAT, while this project specifically aims to identify auto/paracrine factors that regulate the interplay of ECs and how ECs adapt to the energetic needs of BAT.
Project Leaders
Prof. Dr. med. Alexander Pfeifer
Universitätsklinikum Bonn
Institut für Pharmakologie & Toxikologie
Venusberg-Campus 1 53127 Bonn
© Johann Saba
Prof. Dr. Kerstin Wilhelm-Jüngling
Universitätsklinikum Bonn
AG Endothelial Signaling & Metabolism
Venusberg Campus 1 53127 Bonn
© Rolf Müller