Project P07

Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages

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© LB/AW

Together with adipocytes, adipose tissue macrophages (ATM) are a substantial component of adipose tissue. Here, beside their classical immune function, they take up and process lipids therefore contributing to lipid metabolism. However, their functional relevance for thermogenic fat is poorly understood. In this project we aim to unravel the role of ATM lipid uptake and processing during activation of thermogenic fat. In particular, we will dissect ATM immune and metabolic function as well as the impact of ATM on adipocyte thermogenic function and on systemic energy metabolism.


Project Leaders

Avatar Bosurgi

Lidia Bosurgi

Ph.D.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf

Martinistr. 52

20246 Hamburg

Bernard-Nocht-Institute for Tropical Medicine

Bernard-Nocht-Str. 74

20359 Hamburg

+49 40 4218-860

Avatar Worthmann

Dr. rer. nat. Anna Worthmann

Building N30, Room 220

Martinistraße 52

20246 Hamburg

University Medical Center Hamburg-Eppendorf

Department of Biochemistry and Molecular Cell Biology

+49 40 7410-59973

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