Regulation of thermogenesis through the aryl hydrocarbon receptor repressor (AhRR) and CYP1 monooxygenases in endothelial cells and preadipocytes
© Reverte Salisa
The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, regulated by the AhR Repressor (AhRR) and CYP1 monooxygenases. We have discovered that AhRR-deficient mice are protected from diet-induced obesity and feature signs of browning. In this project, we want to investigate the influence of AhR regulators on the interaction of preadipocytes and endothelial cells with brown/beige adipocytes to ultimately identify AhR-dependent mediators regulating thermogenesis.
Project Leader
Dr. rer. nat. Laia Reverte Salisa
Life & Medical Sciences Institute (LIMES)
Carl-Troll-Straße 31
53115 Bonn
© Reverte Salisa