Project P09

Paracrine fibroblast growth factors as metabolic messengers between adipose tissue cells

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The presence of thermogenic uncoupling protein 1 (UCP1) is thought to be a unique feature of fully differentiated brown adipocytes. Several paracrine fibroblast growth factors (FGF) induce the expression of UCP1 in undifferentiated pre-adipocytes. In this project, we aim to determine the specific FGF dominantly constituting this signaling axis in vivo, identify the origin of this factor and thus decipher all components of this novel intra-organ adipose tissue signaling network. We will further employ UCP1-expressing pre-adipocytes as a novel model in which to study the potency of UCP1 interacting proteins.

Project Leaders

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Dr. Tobias Fromme

Chair for Molecular Nutrional Medicine, TU Munich

Gregor-Mendel-Straße 2

85354 Freising

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