Projects
The CRC/TRR research program is divided into 20 projects, each one focusing on a different aspect within the metabolism of brown adipose tissue. Every partner has its own special field of expertise and is an adept in the use of certain technologies. By combining these abilities, excellent research on the field of brown and beige fat tissue is realised.
P02
Impact of intestinal lipophilic metabolites on thermogenic responses by brown and white adipose tissue
Project Leader: Prof. Dr. Jörg Heeren
P03
Targeting GPR116 (Adgrf5) to preserve endothelial identity and restore thermogenic fat function
Project Leader: Dr. Anastasia Georgiadi & Prof. Dr. Stephan Herzig
P05
Relevance of vascularization and endothelial lipoprotein processing for thermogenic adipose tissue plasticity and function
Project Leader: Prof. Dr. Jörg Heeren & Prof. Dr. Kerstin Wilhelm-Jüngling
P07
The role of efferocytosis during involution of thermogenic adipose tissues
Project Leader: Dr. Lidia Bosurgi & Dr. Anna Worthmann
P08
Regulation of thermogenesis through the aryl hydrocarbon receptor repressor (AhRR) and CYP1 monooxygenases in endothelial cells and preadipocytes
Project Leader: Dr. Laia Reverte Salisa
P09
Fibroblast growth factor induced uncoupling protein 1 expression in preadipocytes causes lasting functional changes in white and brown adipocytes
Project Leader: Dr. Tobias Fromme
P10
Analyzing the role of ciliary cAMP signaling in controlling BAT development and function
Project Leader: Prof. Dr. Dagmar Wachten
P11
Purinergic crosstalk in thermogenic fat – The cGMP signalosome in brown/beige adipocytes
Project Leader: Prof. Dr. Alexander Pfeifer
P12
The role of ACTH and glucocorticoid signaling in brown fat metabolism
Project Leader: Prof. Dr. Henriette Uhlenhaut & Prof. Dr. Yongguo Li
P13
The role of ChREBP in the regulation of metabolic and thermogenic activities of brown adipose tissue
Project Leader: Dr. Ludger Scheja
P15
Impact of MECR on plasmalogen lipid metabolism and thermogenesis in brown adipocytes
Project Leader: Dr. Dr. Christian Schlein
P16
Elucidating the regulation and function of lipid droplet mitochondrial contacts in BAT thermogenesis
Project Leader: Dr. Natalie Krahmer
P17
Post-translational regulation of DGAT1, futile lipid cycling and energy expenditure
Project Leader: Prof. Dr. Martin Klingenspor & Dr. Natalie Krahmer
P18N
Brown Fat Organoids Development and Crosstalk
Project Leader: Prof. Dr. Yongguo Li & Prof. Dr. Alexander Pfeifer
P20N
Role of UBE2H in brown fat proteostasis and metabolism
Project Leader: Prof. Dr. Alexander Bartelt & Dr. Dr. Christian Schlein
P21N
Volatile Organic Compound (VOC) Odorants to Activate Energy Expenditure
Project Leader: Prof. Dr. Katharina Timper
S01
Computational Biology Unit
Project Leader: Prof. Dr.-Ing. Jan Hasenauer
S02
Functional Proteomics/ Lipidomics/ Metabolomics and Human Thermogenic Adipocyte Unit
Project Leader: Prof. Dr. Felix Meissner, Prof. Dr. Jörg Heeren & Prof. Dr. Alexander Pfeifer
iRTG
Module Integrated Research Training Group
Project Leader: Prof. Dr. Klingenspor, Dr. Worthmann & Prof. Dr. Li
A structured interdisciplinary training program will provide highly specialized and targeted training in the research area of the CRC/TRR333. Doctoral researchers will be prepared to face the overarching demand of ‘BATenergy research’ skills. In addition, local graduate schools will provide key skill training opportunities and career development coaching. Valuing networking, collaborative research, scientific exchange and internationalization will foster self-confidence of young scientists and lay grounds for a successful scientific career.
18
Projects
2
Service Projects
1
Integrated Research Training Group
Contact
Prof. Dr. med. Alexander Pfeifer
Institut für Pharmakologie & Toxikologie, Universitätsklinikum Bonn, Universität Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Simona Braams
Institut für Pharmakologie & Toxikologie, Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn